Pharm-17A8 Compare and contrast low-molecular-weight heparin and unfractionated heparin.

Pharm-14B8 Outline the important pharmacological considerations when stopping warfarin and commencing prophylactic (low dose) low molecular weight heparin (LMWH) in the peri-operative period. (als0 Pharm-07B2)

Pharm-12B01 How does warfarin exert its anti-coagulant effect? What methods can be used to reverse the effects of warfarin prior to surgery? 64%

Pharm-11B5 Describe the mechanism of action of protamine when used to reverse the effects of heparin. Outline the side effects of protamine. (also Pharm-95A8)

Pharm-08B7 List the agents used to therapeutically reduce platelet function. Outline their mechanism of action, adverse effects, mode of elimination and duration of action. (also Pharm-05A5)

Pharm-04A8 Describe briefly the side effects and complications of heparin therapy. (also Pharm-95B4)

Pharm-02A15 Describe the mechanism of the anticoagulant effect of coumarin derivatives and what determines the onset and offset of action.

Pharm-99A15 List the drugs used clinically as anti-coagulants and anti-thrombotics. Write short notes on the mechanisms of their actions. 65%

Pharm-95A10 Outline the importance of vitamin K and the factors determining its uptake.


One thought on “Anticoagulants

  1. Re Oral bioavailability for Vitamin K from medsafe data sheet NZ

    A pharmacokinetic study indicated that the MM solution of vitamin K1 administered orally is rapidly and effectively absorbed from the small intestine. Absorption is limited in the absence of bile.
    Oral doses of vitamin K1 are absorbed primarily from the middle portions of the small intestine. Systemic availability following oral dosing is approximately 50%, with a wide range of interindividual variability. Onset of action occurs approximately 1–3 hours after IV administration and 4–6 hours after oral doses.


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